Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Functional interactions between NURF and Ctcf regulate gene expression.
Control of embryonic stem cell lineage commitment by core promoter factor, TAF3. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Rok regulates yuaB expression during architecturally complex colony development of Bacillus subtilis 168. Topological domains in mammalian genomes identified by analysis of chromatin interactions. Defined chromosome structure in the genome-reduced bacterium Mycoplasma pneumoniae. Multiple regulatory systems coordinate DNA replication with cell growth in Bacillus subtilis. XerD unloads bacterial SMC complexes at the replication terminus. Antibiotic-induced replication stress triggers bacterial competence by increasing gene dosage near the origin. How bacterial xenogeneic silencer rok distinguishes foreign from self DNA in its resident genome. The transcriptional regulator Rok binds A+T-rich DNA and is involved in repression of a mobile genetic element in Bacillus subtilis. The rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions. Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comK. Genetic and biochemical interactions between the bacterial replication initiator DnaA and the nucleoid-associated protein Rok in Bacillus subtilis. Density gradient ultracentrifugation to isolate endogenous protein complexes after affinity capture. Grad-seq guides the discovery of ProQ as a major small RNA-binding protein. Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression. Insulators: many functions, many mechanisms. Long-range enhancer–promoter contacts in gene expression control. Condensin- and replication-mediated bacterial chromosome folding and origin condensation revealed by Hi-C and super-resolution imaging. Physical and functional compartmentalization of archaeal chromosomes. Distinct activities of bacterial condensins for chromosome management in Pseudomonas aeruginosa. Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus. Condensin-based chromosome organization from bacteria to vertebrates. Chromosome organization in bacteria: mechanistic insights into genome structure and function. Transcription rate and transcript length drive formation of chromosomal interaction domain boundaries. Chromatin domains: the unit of chromosome organization. Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation. Insulators are fundamental components of the eukaryotic genomes. Cohesins functionally associate with CTCF on mammalian chromosome arms. CTCF: an architectural protein bridging genome topology and function. Roles of chromatin insulators in the formation of long-range contacts. Three-dimensional folding and functional organization principles of the Drosophila genome. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Principles of genome folding into topologically associating domains. coli chromosome by nucleoid-associated and condensin proteins. Organization and segregation of bacterial chromosomes.
Bacterial chromosome organization and segregation. High-resolution mapping of the spatial organization of a bacterial chromosome.
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